Journal: eLife
Article Title: Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
doi: 10.7554/eLife.93260
Figure Lengend Snippet: The boxplots captured the standardized maternal smoking methylation scores (y-axis) stratified by study. The top panels summarized results for all samples in Canadian Healthy Infant Longitudinal Development (CHILD; n=352), Family Atherosclerosis Monitoring In early life (FAMILY; n=411), and SouTh Asian biRth cohorT (START; n=504), while the bottom panels summarized results for only those in CHILD, FAMILY, and START that never smoked. The p -values indicate the significance for a mean difference for each pairwise comparison between the HM450K score validated in CHILD with other scores using two-sample t -tests.
Article Snippet: About half of the START samples and selected samples from CHILD were hybridized to the Illumina Human-Methylation450K BeadChip (HM450K) array, which covers CpGs in the entire genome ( ) The raw methylation data were generated by the Illumina iScan software and separately pre-processed for START and CHILD using the ‘ sesame’ R package following pipelines designed for HM450K BeadChip ( ).
Techniques: Methylation, Comparison